abstract：:A phase II clinical study was performed to evaluate the effectiveness and toxicity of cladribine (2-CdA) combined with mitoxantrone (CM regimen) in the treatment of chronic myeloid leukemia in blastic phase (CML BP). A total of 12 adult patients with CML BP were included in this study. 2-CdA was given at a dose 0.12 m...

journal_title：Neoplasma

authors： Robak T,Góra-Tybor J

更新日期：2001-01-01 00:00:00

abstract：:Cysteine proteinases cathepsin (Cath) B and L and their endogenous inhibitors stefin (Stef) A and B concentrations were measured using a quantitative immunosorbent assay (ELISA; KRKA d.d., Novo mesto, Slovenia) in serum samples from 35 patients with primary and 7 patients with recurrent squamous cell carcinoma of the ...

journal_title：Neoplasma

authors： Strojan P,Budihna M,Smid L,Svetic B,Vrhovec I,Skrk J

更新日期：2001-01-01 00:00:00

abstract：:The oral cavity is continually exposed to various traumas due to the effect of thermal, mechanical and chemical stimuli, which when accompanied by inflammatory states may promote the growth of neoplastic changes. Numerous studies have revealed a correlation between the expression of p53 and Bcl-2 proteins and the prog...

journal_title：Neoplasma

authors： Sulkowska M,Famulski W,Chyczewski L,Sulkowski S

更新日期：2001-01-01 00:00:00

abstract：:In this study subcellular localization of cyclin A in the human promyelocytic leukemia cell line HL-60 and the human erythroleukemic K-562 cell line was examined by immunocytochemical methods. Studies were based on light and electron microscope evaluations. Cyclin A at the level of light microscope was present in 48% ...

journal_title：Neoplasma

authors： Grzanka A,Styczynski J

更新日期：2001-01-01 00:00:00

abstract：:This paper deals with determination of potential carcinogenic and inhibitory activity of 10 compounds isolated from the ethanolic extract of Lilium candidum L. perfonned by DC polarography. The series of investigated compounds consisted of two spirostanol saponins, two pyroline derivatives, jatropham and its glucoside...

journal_title：Neoplasma

authors： Vachálková A,Eisenreichová E,Haladová M,Mucaji P,Józová B,Novotný L

更新日期：2000-01-01 00:00:00

abstract：:High-dose chemotherapy (HDC) in high-risk breast cancer is one of the possible approaches how to improve therapeutic results, eventually, to overcome the incurability of the disease. In recent randomized studies superiority of HDC to conventional therapy has not been unambiguously established. Nevertheless, many oncol...

journal_title：Neoplasma

authors： Filip S,Petera J,Odrázka K,Bláha M

更新日期：2000-01-01 00:00:00

abstract：:Glial fibrillary acidic protein (GFAP), vimentin (Vi) and cytokeratin (CK) intermediate filament (IF) proteins were studied in glioblastoma cell line GL-15. The immunofluorescence staining revealed strong positive staining for vimentin in all cultured cells. Approximately 20% of analyzed cells showed strong and 50% mo...

journal_title：Neoplasma

authors： Perzelcová A,Máciková,Tardy M,Mráz P,Steno J,Bízik I

更新日期：2000-01-01 00:00:00

abstract：:Combination of corticosteroids with new purine analogs such as cladribine 2-chlorodeoxyadenosine, (2-CdA) and fludarabine (FAMP) is controversial. The possibility of potentiation of antineoplastic activity of 2-CdA or FAMP by corticosteroids has not been documented so far. On the other hand, such combination may incre...

journal_title：Neoplasma

authors： Robak T,Szmigielska A

更新日期：2000-01-01 00:00:00

abstract：:Cisplatin-based chemotherapy is highly effective in advanced seminoma, but at the cost of a considerable toxicity. The response rate of carboplatin is comparable with cisplatin combinations but the relapse rate is higher. Our study assesses the efficacy and the toxicity of the combination of carboplatin and cyclophosp...

journal_title：Neoplasma

authors： Mardiak J,Sálek T,Sycova-Milá Z,Sufliarsky J,Baláz M,Koza I

更新日期：2000-01-01 00:00:00

abstract：:During the last 30 years the trends in cancer mortality in Europe significantly changed. In 1970 the male and female cancer mortality (all ages) was higher in the Western Europe than in the "socialist" Central and Eastern Europe. After 1970 in most Western countries decrease or no change of male premature (0-64 years)...

journal_title：Neoplasma

authors： Ginter E

更新日期：2000-01-01 00:00:00

abstract：:Tamoxifen belongs among relatively new drugs. As it has already been shown, it undoubtedly brings a benefit to oncology patients. However, there are still questions regarding its broader use in therapy or cancer prevention. This review puts together some data available at present time with the aim of elucidating the m...

journal_title：Neoplasma

authors： Novotny L,Rauko P,Vachálková A,Peterson-Biggs M

更新日期：2000-01-01 00:00:00

abstract：:Treatment with interferon-alpha (IFNalpha) prolongs survival in chronic myeloid leukemia (CML). Additionally, cytarabine (AraC) can reduce the number of Ph + metaphases. Fortythree previously untreated patients with CML in chronic phase were randomly assigned to receive either. IFNalpha 2b (5 MU sqm/daily) or IFNalpha...

journal_title：Neoplasma

authors： Tóthová E,Fricová M,Kafková A,Stecová N,Guman T,Raffac S,Hlebasková M

更新日期：2000-01-01 00:00:00

abstract：:Molecular genetic studies have revealed mutations in a number of oncogenes and tumor suppressor genes in lung cancer. The bcl-2 gene product (bcl-2 protein) is implicated in oncogenesis by its ability to prolong cell death through the inhibition of apoptosis. We investigated expression of bcl-2 in 84 resected human no...

journal_title：Neoplasma

authors： Laudanski J,Chyczewski L,Niklińska WE,Kretowska M,Furman M,Sawicki B,Nikliński J

更新日期：1999-01-01 00:00:00

abstract：:Age over 65 years is a risk factor per se for doxorubicin administration, and coexisting diseases pose additional problems. There is still controversy whether chemotherapy regimens for elderly patients with aggressive NHL should be full-dose doxorubicin containing or whether development of non-anthracycline containing...

journal_title：Neoplasma

authors： Jelić S,Milanović N,Tomasević Z,Matković S,Gavrilović D

更新日期：1999-01-01 00:00:00

abstract：:Therapeutic cells producing amphotropic retrovirus, which are able to transduce in vivo thymidine kinase gene of Herpes simplex virus were prepared. Single-cell clone cells with high virus productivity (PA-3 17JH5c113) were obtained by cell cloning. The cells were found free of replication competent retrovirus, they w...

journal_title：Neoplasma

authors： Hlavatý J,Hlubinová K,Bies J,Altaner C

更新日期：1999-01-01 00:00:00

abstract：:Since the prevention of apoptosis can produce resistance to chemotherapy, abnormal expression of oncoproteins engaged in the regulation of this phenomenon in tumor cells may give some prognostic information in patients with neoplasma. To assess this problem in Hodgkin's disease (HD), the cellular expression of two p53...

journal_title：Neoplasma

authors： Smolewski P,Niewiadomska H,Krykowski E,Robak T

更新日期：1999-01-01 00:00:00

abstract：:The polarographic reduction of six synthetic 1,3,6-triazine (6-aza) nucleosides with 6-azauracil as the nucleoside base in the strictly anhydrous solutions was studied in the absence and presence of alpha-lipoic acid. The values of the half-wave potentials E1/2 and the parameter of potential carcinogenicity tg alpha w...

journal_title：Neoplasma

authors： Novotný L,Vachálková A,Pískala A

更新日期：1999-01-01 00:00:00

abstract：:Alteration of the p53 tumor suppressor gene is the most common genetic defect known to occur in human tumors. Germ-line p53 mutations significantly increase the risk of developing diverse malignancies. FASAY is a simple functional assay for germ-line and somatic mutations in the p53 gene altering the transactivation c...

journal_title：Neoplasma

authors： Smardová J

更新日期：1999-01-01 00:00:00

abstract：:The aim of our study was to evaluate the efficacy of oral clodronate supplementing systemic therapy and/or palliative irradiation in 91 patients with painful bone metastases. Clodronate was administered at a daily dose of 1600-3200 mg for a median of 11 months (range 3--36 months). Partial or complete pain relief was ...

journal_title：Neoplasma

authors： Serkies K,Jereczek-Fossa B,Badzio A,Jassem J

更新日期：1999-01-01 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF-alpha) a proinflammatory cytokine with multiple actions was first identified for its anticancer activity. However, TNF-alpha has a beneficial function in activation of host defense, its uncontrolled production can lead to pathological consequences. At the cellular level, it is able to ...

journal_title：Neoplasma

authors： Szatmáry Z

更新日期：1999-01-01 00:00:00

abstract：:The macrocyclic Cu(II)-tetraanhydroaminobenzaldehyde complex Cu(TAAB)C12 induces various cytotoxic effects in the dependence on a cell line, concentration and time of exposition. The highest complex concentration of 914 nmol/l induces degeneration of certain part of the HeLa cells population after 24 hours of cultivat...

journal_title：Neoplasma

authors： Jantová S,Duracková Z,Novotný L,Urbancíková M,Dovinová I,Labuda J,Wsolová L

更新日期：1998-01-01 00:00:00

abstract：:Drug resistance is a prominent problem of cancer therapy. Differences in quantity and quality of many metabolites in normal and malignant cells and their changes after treatment by anticancer drugs can be detected by nuclear magnetic resonance (NMR) both in vivo and in vitro. The results of in vivo and in vitro 1H, 13...

journal_title：Neoplasma

authors： Hanusovská E,Dovinová I,Tkác I,Novotný L

更新日期：1998-01-01 00:00:00

abstract：:The authors have studied the influence of two kinds of transplantable melanomas on the secretion of oncostatin M (OSM) and total proteins by peritoneal macrophages. Culture supernatant samples were tested by ELISA. The macrophages of melanoma-bearing animals released a lower amount of OSM than those of the controls. A...

journal_title：Neoplasma

authors： Kozłowska K,Cichorek M,Zarzeczna M

更新日期：1998-01-01 00:00:00

abstract：:Granulocyte colony-stimulating factor (G-CSF) was found to exert antitumor activity against murine MmB16 melanoma when administered intratumorally. However, subcutaneous administration of this cytokine at a site distant from the growing tumor did not show any antitumor effects. G-CSF did not influence the proliferativ...

journal_title：Neoplasma

authors： Gołab J,Zagozdzon R,Stokłosa T,Kaca A,Dabrowska A,Giermasz A,Feleszko W,Jakóbisiak M

更新日期：1998-01-01 00:00:00

abstract：:This paper summarizes preliminary results of combining suicide gene strategy (E. coli cytosine deaminase gene--CD) with immunotherapy (murine interleukin-4 gene) for treatment of experimental B16(F10) melanomas implanted into C57Bl/6 mice. The best therapeutic results, inhibition of tumor growth and prolonged survival...

journal_title：Neoplasma

authors： Missol-Kolka E,Sochanik A,Szala S

更新日期：1998-01-01 00:00:00

abstract：:Ninety-five squamocellular carcinomas of the uterine cervix, clinical Stages II and III, were treated by either four schedules combining 252-californium neutron-gamma-radiotherapy with different proportions of a neutron component (9, 6 and 3 Gy) or gamma-irradiation alone. Flow cytometric DNA profiles were obtainable ...

journal_title：Neoplasma

authors： Tacev T,Zaloudík J,Janáková L,Vagunda V

更新日期：1998-01-01 00:00:00

abstract：:Cytogenetic studies in Chinese hamster ovary (CHO) cells using aqueous and organic extracts of pan masalas, as well as genomic damage observed among pan masala consumers have conclusively shown genotoxic potential of pan masala-a dry complex mixture of areca nut, lime, catechu, cardamom, unspecified flavoring agent, e...

journal_title：Neoplasma

authors： Patel RK,Trivedi AH,Jaju RJ,Kukreti MS,Bhatavdekar JM,Shah PM,Patel DD

更新日期：1998-01-01 00:00:00

abstract：:Cytokinesis-block micronucleus assay (CB-MNA) was applied for comparison of radiation sensitivity of 25 human malignant melanomas in primary culture. Cells obtained from tumor specimens were irradiated (0-4.Gy) on dishes, incubated with cytochalasin B (2 micrograms/ml) to block cytokinesis, stained in situ and micronu...

journal_title：Neoplasma

authors： Wideł M,Dobrut M,Maka B,Lubecka B,Pluciennik A

更新日期：1997-01-01 00:00:00

abstract：:Many reports indicate that glutathione and enzymes cooperating with it are important in neoplastic processes. Glutathione (GSH) concentrations and glutathione S-transferase (GSH STr) and glutathione peroxidase (GSH-Px) activities were determined in breast cancer tissue and adjacent healthy tissues, as well as in blood...

journal_title：Neoplasma

authors： Gromadzińska J,Wasowicz W,Andrijewski M,Skłodowska M,Quispe OZ,Wołkanin P,Ołborski B,Płuzańska A

更新日期：1997-01-01 00:00:00

abstract：:The expression of cytokeratins 7, 8, 14, 18, 19 and vimentin was examined in 100 cases of ductal invasive breast carcinomas. While the predominantly diffuse immunohistological positivity of simple epithelia cytokeratins 7 (in 93), 8 (in 100), 18 (in 100) and 19 (in 97) cases represents a constant feature of these tumo...

journal_title：Neoplasma

authors： Rejthar A,Nenutil R

更新日期：1997-01-01 00:00:00

abstract：:Serum concentration of alpha1-proteinase inhibitor (alpha1-PI) was determined by nephelometric method in forty seven patients with liver cirrhosis (LC) and fifteen patients with hepatocellular carcinoma (HCC). Our data show an increase in the concentration of alpha1-PI in the group with decompensated LC by 17% and in ...

journal_title：Neoplasma

authors： Dabrowska M,Mantur M,Panasiuk A,Prokopowicz J

更新日期：1997-01-01 00:00:00

abstract：:Family history of colorectal cancer is recognized as a risk factor for the disease and the development of colorectal cancer represents a suitable model for illustrating multistep tumor development. Bleomycin induced chromosome sensitivity studies were done in 7 colorectal cancer families consisting of 12 colorectal ca...

journal_title：Neoplasma

authors： Jyothish B,Ankathil R,Chandini R,Vinodkumar B,Nayar GS,Roy DD,Madhavan J,Nair MK

更新日期：1997-01-01 00:00:00

abstract：:The distribution study of zinc phthalocyanine disulfonate (ZnPcS2) in nude mice bearing mammary carcinoma (T50/80) revealed a rapid uptake of the dye by tumor. In experimental photodynamic therapy (PDT), the tumors were exposed to laser radiation (670 nm, 100 mW/cm2, 150 J/ /cm2) after intravenous administration of Zn...

journal_title：Neoplasma

authors： Mosa M,Zitko M,Poucková P

更新日期：1997-01-01 00:00:00

abstract：:Red cell antioxidant enzymes have been recently studied in malignant lymphomas and the results are controversial. Hairy cell leukemia is a rare chronic lymphoproliferative disorder originating probably in a pluripotent stem cell. In the present study, glutathione peroxidase (Gpx), reduced glutathione (GSH), superoxide...

journal_title：Neoplasma

authors： Arruda VR,Salles TS,Costa FF,Saad ST

更新日期：1996-01-01 00:00:00

abstract：:Twenty eight patients with germ cell testicular cancer pulmonary metastases received primary chemotherapy including bleomycin, etoposide, and cisplatin (BEP). Complete response was achieved in 21 (75%) patients, in 11 of them CR was achieved following chemotherapy alone. Postchemotherapy surgery of residual mass was p...

journal_title：Neoplasma

authors： Schnorrer M,Ondrus D,Cársky S,Hornák M,Belan V,Kausitz J,Matośka J

更新日期：1996-01-01 00:00:00

abstract：:The antitumor activity of phthalmustine (Neoplasma, 41, 1994, 35) has been evaluated in murine Ehrlich ascites carcinoma (EAC) and sarcoma-180 (S-180). The hematological changes associated with the application of phthalmustine were also evaluated in tumor bearing as well as in normal male Swiss mice. The results indic...

journal_title：Neoplasma

authors： Bhattacharya S,Ghosh M,Sadhu U,Dutta S,Sanyal U

更新日期：1996-01-01 00:00:00

abstract：:The paclitaxel represents first agent from novel class of antineoplastic drugs-taxoids. The clinical development of paclitaxel was initially hampered by hypersensitivity reactions. Current dosage regiments with premedication reduced the incidence of these side effects to less than 3%. The major dose-limiting adverse e...

journal_title：Neoplasma

authors： Hájek R,Vorlicek J,Slavik M

更新日期：1996-01-01 00:00:00

abstract：:Leukemia-associated phenotypes have been suggested to be a valuable tool for the detection of minimal residual disease in acute leukemia patients, as they allow to distinguish leukemic blasts from normal hematopoietic progenitor cells. The aim of the present study was to analyze the proportion of acute leukemia patien...

journal_title：Neoplasma

authors： Babusíková O,Glasová M,Koníková E,Kusenda J

更新日期：1996-01-01 00:00:00

abstract：:The growth of transplanted Bomirski melanoma in hamsters is accompanied by the decrease of natural killer cytotoxic activity and the formation of metastases. The excision of primary tumors was carried out to examine what was the effect of the growing tumor and its metastases on the host's NK activity. It was found tha...

journal_title：Neoplasma

authors： Myśliwski A,Sosnowska D,Bigda J

更新日期：1996-01-01 00:00:00

abstract：:All cases of Hodgkin's disease (HD) and non-Hodgkin's lymphoma (NHL) reported to the Kuwait Cancer Registry between 1980-1989 were analyzed. Age specific and age standardized incidence rates were calculated for Kuwaiti and non-Kuwaiti males and females for the two periods of 1980-1984 and 1985-1989, and compared to de...

journal_title：Neoplasma

authors： al-Bahar S,Pandita R,al-Bahar E,al-Muhana A,al-Yaseen N

更新日期：1996-01-01 00:00:00